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This epigenetic alteration results in cancer progression, drug resistance [34], metastasis and stemness induction [35, 36], metabolic alterations by affecting enzymes involved in the tricarboxylic acid cycle (TCA), and carbohydrate, amino acid, fatty acid, and nucleotide metabolism [35], hence opening the way to the generation of novel therapeutic strategies against lysine lactylation, not only regarding histones (Fig
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Briefly, a survey scan m / z 3501750 was acquired in the orbitrap (resolution = 120,000 at m / z 200, with an accumulation target value of 400,000 ions) and lockmass enabled ( m / z 445.12003)
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